琺瑯質 形成期間동안 全身的으로 投與된 弗素가 發育中인 琺瑯質에 미치는 影響에 關한 實驗的 硏究
AN EXPERIMENTAL STUDY OF THE EFFECTS OF FLUORIDE ADM IMISTERED SYSTEMICALLY DURING ENAMEL FORMATION ON DEVELOPING ENAMEL
소속 상세정보
이영림(李英林)/Young-Lim Lee
손동수(孫同銖)/Dong-Su Shon
KMID : 0358919870140010199
Abstract
結 論
畿瑯質 形成刻間中에 全身的으로 拔與된 弗素가 發育中인 琺瑯質에 미치는 影響을 알아
보기 爲하여 幼若白鼠를 對象으로 弗化소다浩液을 皮下汪射한 後萌出直前의 下顎第一大臼齒
를 拔去하여 酸腐蝕生檢法, 弗素이온電極, 原子吸頻分光機 및 X-線 被長分散分光機를 利用
하여 琺瑯質의 弗素濃度와 溶解度를 測定하고, 走基電予顯微鏡으로 珹瑯質의 表面 및 斷衛
의 構造를 觀察하여 다음과 같은 結論을 얻었다.
1. 琺瑯質 形成期間中 弗素를 全身投與한 結果, 琺瑯質의 弗素濃度는 增加하고, 溶解度는
減少하였으며, 琺瑯質의 弗素濃度와 溶解度는 逆相關關係를 나타냈다 (相關係數 : -0.7829).
2. 琺瑯質 弗素濃度의 增加 및 溶解度의 增加 및 溶解度의 減少는 弗素全身投與를 일찍
始作할수록, 全身技與 期問이 길수록, 全身投輿量이 많을수륵 크게 나타났으며, 萌出前 1回
만 投與한 境遇는 生後 5日에 投與한 群에서 가장 크게 나타났다.
3 弗素注射祥은 對照群보다 琺瑯質 全層에서 弗素濃度가 높았다(P<0.01).
4. 弗素注射群과 對照祥 모두 琺瑯質 表面에서 20μm깊이까지의 弗素濃度가 다른 曆에
比해 낮았다 (P<0.05).
5. 弗素注射祥에서 琺瑯質 構造의 變化가 觀察 되었다.
The purpose of this study is to evaluate the effects of fluoride administered
systemically during enamel formation on developing enamel experimentally. Subcutaneous
injections of sodium fluoride solution were given to the Sprague-Dawley rat pups at
various days of age and with various daily doses. At 14 days of age, the rats were
sacrificed, the mandibular first molars were extracted, and the enamel was sampled
using acid-etching biopsy.
The fluoride concentration and the solubility of enamel were measured using fluoride
ion electrode, atomic absorption spectrophotometer and wavelength dispersive X-ray
spectrometer, and the structure of enamel was observed using scanning electron
microscope.
The following results were obtained;
1. The fluoride concentration of enamel was increased and the solubility decreased
following systemic administration of fluoride during enamel formation. There was a
negative correlationship between the fluoride concentration and the solubility of enamel.
(correlation coefficient; -0.7829)
2. There was a trend showing that the earlier the fluoride administration was started,
the longer continued and the more fluoride dose was administered, the more the fluoride
concentration of enamel was increased and the solubility decreased. If the fluoride
administration was done once before eruption, the amount of increase in fluoride
concentration and decrease in solubility was most in the group which was administered
on 5 days of age.
3. The fluoride concentration of enamel in the F-injected group was higher than that
in the control group at all depths of enamel (p<0.01),
4. The fluoride concentration of enamel was lower at 20 μm deep layer from enamel
surface than the other layers of enamel both in the F-injected group and in the control
group(p<0.05).
5 The structural change of enamel was observed in the F-injected group.
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